It is not surprising that over the past decades, many researchers have searched for theories and research tools in the area of semiotics to explore translation issues. Translation constitutes a semiotic act, since there is transition from one semiotic system to another, verbal or nonverbal. It is true that semiotics can become the mediator among the sciences of meaning. The most important reason why semiotics can perform this role is because, as Gilles Deleuze states, it is a science descriptive of the reality, the everyday culture. So it is the most appropriate research field to contribute to the study of translation, a purely cultural act. The relation between semiotics and translation is presented in this chapter from a sociosemiotic and critical perspective.