We study the possible connection between self-consciousness and quantum process. It is shown that the self-consciousness function can help to measure the collapse time of wave function under some condition, while the usual physical device without self-consciousness can't. Furthermore, we show that the observer with self-consciousness can distinguish the definite state and the superposition of definite states under some stronger condition. This provides a practical physical method to differentiate man and machine, and will also help to find the possible existence of self-consciousness in the animal kingdom. We finally give some further discussions about these new results.